Tsinghua University

Gp Medical, Inc.

Min-Fan Chung

Hsing-Wen Sung

Zi-Xian Liao

Hosheng Tu

Ko-Jie Chen

Chun-Wen Hsiao

Po-Yuan Cheng

Chieh-Cheng Huang

Wei-Lun Chiang

An (acid-substituted polyaniline)-grafted hydrogel copolymer is provided. The (acid-substituted polyaniline)-grafted hydrogel copolymer has a general formula as below: wherein A is a proton acid group, m and n are same or different integers greater than 0, x is an integer equal to or greater than 0, and y is an integer equal to or greater than 1, provided that x and y are the same or different at each occurrence, and at least an x is not 0. The (acid-substituted polyaniline)-grafted hydrogel copolymer is formed by the polymerization and substitution reaction between chitosan, polyaniline, and proton acid. The (acid-substituted polyaniline)-grafted hydrogel copolymer behaves as a pH-responsive hydrogel with photo-thermal properties and can be applied to photo-thermal therapy.

Acid-substituted polyaniline-grafted hydrogel copolymer and use thereof

The invention discloses a pharmaceutical composition of pH-sensitive liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein the compound is in vesicles of the liposomes. A light or UV light is provided to induce the photosensitive compound to release the protons, thus the released protons causing the pH-sensitive liposome to decompose.

Pharmaceutical composition of nanoparticles

The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.

Growing community of inventors

Hsinchu, Taiwan

Min-Fan Chung