Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Cspc Nbp Pharmaceutical Co., Ltd.

Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Min Bai

Ying Shi

Yi Mi

Hanyu Yang

Qingzhi Gao

Yujie Chen

Yuxiu Ma

Xiaozhuo Chen

Xuejiao Zhang

Wenmin Guo

Xuliang Wang

Wen-juan Liu

Gui-rong Zhou

Chao Liu

Rong-duan Wang

Hong-zhong Yuan

Wen-min Guo

Sui-chao Yan

Zhan-qi Niu

Guirong Zhou

Liyun Liu

Surui Chen

Jianqing Li

Denghuang Gong

Kai Zhao

Gui-Rong Zhou

Wen-Min Guo

Sui-Chao Yan

Wen-Juan Liu

Rong-Duan Wang

Hong-Zhong Yuan

Zhan-Qi Niu

The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R, Z and Q are as described in the description. 

Benzamide derivative

The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0&#x2dc;10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2&#x2dc;0.4:0.8&#x2dc;1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavor of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China.

Soft capsule of butylphthalide and a process for preparing the same

The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-&#x3b2;-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.

Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof

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Hebei, China

Min Bai