Boehringer Ingelheim International Gmbh

Avantium International B.v.

Boehringer Ingelheim Pharma Gmbh & Co Kg

Mimoun Lamkadmi

Benjamin McKay

Mihaela Pop

Emilio René Bodenstaff

Danny Dirk Pieter Willem Stam

Stéphanie Houdayer Mulder

Stéphanie Mulder Houdayer

Mihaela Maria Pop

Benjamin Mckay

A system for determining a solubility of a substance comprises a holder to hold a sample comprising an amount of the substance and an amount of the solvent system. The system further comprises a temperature conditioner to alter a temperature of the sample, an optical measurement device to measure an optical parameter of the sample and a control device to control at least the temperature conditioner and the optical measurement device. The control device may be programmed to alter the temperature of the sample by the temperature conditioner, measure the optical parameter of the sample by the optical measurement device, and determine the solubility of the substance from a change of the optical parameter of the sample as a function of the temperature.

System and method for solubility curve and metastable zone determination

The invention relates to a new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Crystalline forms of tiotropium bromide

Growing community of inventors

Rotterdam, Netherlands

Mimoun Lamkadmi