American Home Products Corporation

Milton Wolf

Richard L Fenichel

Richard P Carlson

Alan J Lewis

A method of modulating the immune response in mammals by administering thereto compounds having the general formula: ##STR1## where R is hydrogen or alkyl of 1-4 carbon atoms, R.sup.1 is hydrogen or an alkyl of 1-4 carbon atoms and pharmaceutically acceptable salts thereof.

Method for modulating the immune response with dibenzocycloheptenylidenes

4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides are immunomodulatory agents useful in the treatment of immune system diseases and disorders.

4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides

A method of treating inflammation in mammals by administering thereto compounds having the general formula: ##STR1## where R is hydrogen or alkyl of 1-4 carbon atoms, R.sup.1 is hydrogen or an alkyl of 1-4 carbon atoms and pharmaceutically acceptable salts thereof.

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West Chester, PA, United States of America

Milton Wolf