Givaudan Corporation

Hoffmann-la Roche Inc.

Milton Manowitz

Harold A Brandman

Joseph A Virgilio

David L Coffen

Emanuel Heilweil

Joachim E Freudewald

Edward J Nikawitz

Frederick H Sharpell, Jr

Alyce Brandman

Albert I Rachlin

William E Newman

Userful as antimicrobial agents in aqeuous systems are .alpha.-halo.beta.-(substituted)thioacrylonitriles of the formula ##STR1## wherein X represents Cl, Br or I and R represents a lower alkyl, aryl, aralkyl, heterocyclo, or a thiocarbonyl group. The configuration about the double bond may be E or Z or a mixture thereof. These compounds provide effective control of microbial growth. The derivatives of formula I are economically prepared from acrylonitrile via a three-step process involving (a) halogenation, (b) dehydrohalogenation and (c) nucleophilic-type displacement. Except for those compounds wherein X is bromo and R is methyl or phenyl, the compounds of formula I are not mentioned in the prior art.

Alpha-halo-.beta.-(substituted)thioacrylonitriles and their use for

This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.

2-alkyl-3-haloisothiazol-3-thione

2-Alkyl-3-haloisothiazolium salts and their derivatives

3-Dicyanomethylene-4-isothiazolines

This disclosure relates to a novel class of 3-alkoxy-2-alkylisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of known antibacterial and antifungal compounds.

3-Alkoxy-2-alkylisothiazolium salts and their derivatives

There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.

Preservation of aqueous systems with 2-chloro-3-oxobutyramide derivatives

Novel iodopropargyl pyridyl and picolinyl ethers and thioethers are effective antifungal agents. They find special utility in paint for protecting finished paint films from fungal attack.

Iodopropargyl pyridyl and picolinyl ethers and thioethers as paint

Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-chloro-.beta.-aminocrotonamide.

Preservation of aqueous systems with

Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-bromo-.beta.-aminocrotononitrile.

Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of an .alpha.-halo-.beta.-aminocrotonic acid ester.

Preservation of aqueous systems with .alpha.-halo-.beta.-aminocrotonic

U.V. absorbing compositions containing substituted N,N'-bis-aromaticformamidines and the use thereof as sun-screening agents.

N,N'-bis-aromaticformamidines useful as sunscreening agents

Novel substituted formamidines are useful as ultraviolet light absorbers, the formamidines being characterized by the formula: ##STR1## wherein: R.sub.1 represents an alkyl group containing one to five carbon atoms;

Growing community of inventors

Wayne, NJ, United States of America

Milton Manowitz