Warner-lambert Company

Astellas Pharma Gmbh

Milton Lethan Pressler

Joseph Thomas Peterson, Jr

Rebecca Guggemos Bakker-Arkema

Maha Ghazzi

Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula wherein R and Rare hydrogen or lower alkyl;

Treatment of congestive heart failure

Disclosed is a method for treating pulmonary hypertension using a vasopressin antagonist.

Treatment of pulmonary hypertension

This invention is a method for preventing or treating postoperative ileus comprising administering a vasopressin antagonist such as a compound of Formula (1), where R , R , and R include hydrogen, halo, alkyl, and alkoxy; R and R are hydrogen or alkyl; R is hydrogen, phenyl, or substituted phenyl, and pharmaceutically acceptable salts thereof.

Method for treating postoperative ileus

ACE inhibitor-MMP inhibitor combinations

Matrix metalloproteinase inhibitors are useful for preventing and treating heart failure, and ventricular dilatation in mammals.

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Saline, MI, United States of America

Milton Lethan Pressler