Monolythix, Inc.

Alfred E. Mann Foundation for Scientific Research

Biology Works LLC

Milton Lee

Keith A Oberg

Mark D Dobbs

Scott P Layne

Ekaterina Tkatchouk

Mark Dobbs

Ivan Rueda

Anthony Spence

Keith Oberg

Scott Layne

The present disclosure relates to a concentrator for concentrating, purifying or otherwise isolating one or more target analytes in a fluid matrix, and related methods, using self-wicking materials, such as monoliths. The present disclosure can be used as a point-of need sample preparation device. The self-contained device can be used for the extraction and concentration of specific target molecules, such as nucleic acids.

Sample concentration devices

The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care/on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.

Monoliths

The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.

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Camarillo, CA, United States of America

Milton Lee