Georgetown University

University of Virginia Patent Foundation

Duke University

University of Oklahoma

Milton L Brown

Yali Kong

Mikell Paige

Kenneth J Kellar

Yingxian Xiao

Sivanesan Dakshanamurthy

Jeffrey A Toretsky

Shujie Hou

Edward D Levin

Aykut Uren

Amir H Rezvani

Yong Liu

Partha Banerjee

Courtney W Houchen

Sripathi M Sureban

Stephen W Byers

Eliot M Rosen

Parthasarathy Chandrakesan

Jacqueline Smith

Venkata Mahidhar Yenugonda

Karishma Amin

Jaime M Guidry Auvil

Aykut Üren

Robert R Clarke

York A Tomita

Thomas H Walls

Perrer N Tosso

Ayesha N Shajahan-Haq

Anatoly Dritschilo

Mira Jung

Christopher S Wilcox

Simeng Suy

Gullay Bulut

Scott Grindrod

Kathryn D Sheikh

Todd Hansen

Shankar Jagadeesh

Saijun Fan

Kathryn E Ditmer

Kan Wang

Jeffrey A Torestsky

George Kosturko

Mikell A Paige

Christopher Stuart Wilcox

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

Radiation mitigator and method of use thereof

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is &#x2014;O&#x2014; or &#x2014;N(H)&#x2014;.

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: 

Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

Small molecule androgen receptor inhibitors and methods of use thereof

Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition metal catalyzed cross-coupling and intramolecular carbazole forming reaction.

Synthesis of mahanine and related compounds

Small molecule inhibitors of XBP1 splicing by IRE1&#x3b1; are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Small molecule inhibitors of XBP1 splicing

The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound.

Fluorescent regulators of RASSF1A expression and human cancer cell proliferation

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

2-halo-5-alkynyl-pyridyl nicotinic ligands

Radioprotector compounds including 3,3'-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.

Radioprotector compounds

The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.

Compounds and methods of use thereof for treating tumors

A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Glutathione-cleavable prodrug and methods of use thereof

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep.

Phenyl-substituted nicotinic ligands, and methods of use thereof

Growing community of inventors

Brookeville, MD, United States of America

Milton L Brown