Applied Research Systems Ars Holding N.v.

Merck Serono S. A.

Laboratoires Serono S.a.

Cytotherapeutics, Inc.

Neurotech S.a.

Milton Harris

Michael James Roberts

Nabil El-Tayar

Wayne Sawlivich

Frank T Gentile

Molly S Shoichet

PEG-IFN-&#x3b2; conjugates, where a PEG moiety is covalently bound to Cysof human IFN-&#x3b2;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&#x3b2;.

Method for producing polyol-IFN-&#x3b2; conjugate

Method for treating disorders and diseases treatable with human fibroblast interferon

PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.

Polyol-IFN-&bgr;conjugates modified at Cys-17 and composition containing same

A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer containing &mdash;CH,&mdash;CH(&mdash;C&equiv;N)&mdash; units, and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.

Membrane formed by an acrylonitrile-based polymer

A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically-active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.

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Huntsville, AL, United States of America

Milton Harris