Miles Laboratories, Inc.

Bayer Corporation

Miles Inc.

Cutter Laboratories, Inc.

Milton B Dobkin

George B Dove

Paul K Ng

Michael A Shearer

Robert E Louie

Paul Ng

Soluble azoles in aqueous solutions can be used as virucidal agents for biologically active protein preparations.

Use of azoles as virucidal agents in solutions of biologically active

Soluble, intermediate length alcohols (C.sub.4 -C.sub.10) in aqueous solutions at low pH (4.0-7.0) can be used as virucidal agents for therapeutic biologically active protein preparations. Treatment with the alcohols is especially useful for proteins having activity not adversely affected by low pH.

Use of intermediate length alcohols as virucidal agents in solutions of

Normal plasma from donors who have not been vaccinated with a varicella-zoster vaccine can be screened for higher than normal titers of naturally occurring antibody to varicella-zoster virus. Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with varicella-zoster infection or at risk to such infection, may receive the present product to raise serum titers of varicella-zoster antibody.

High titer varicella-zoster immune globulin for intravenous

Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to respiratory syncytial virus (e.g. minimum ELISA titer of at least 1:110,000). Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with respiratory syncytial virus infection or at risk of such infection, may receive the present product to raise serum antibody titers to respiratory syncytial virus. Resultant product has an ELISA anti-RSV titer of at least about 1:250,000.

Method of preparing high titer anti-respiratory syncytial virus

High titer anti-respiratory syncytial virus intravenous immune globulin

Normal plasma from donors who have not been vaccinated with a cytomegalovirus vaccine can be screened for higher than normal titers of naturally occurring antibody to cytomegalovirus. Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune serum globulin. The product may be treated to render it suitable for intravenous injection. Patients with cytomegalovirus infection or at risk to such infection, may receive the present product to raise serum titers of cytomegalovirus antibody.

High titer cytomegalovirus immune serum globulin

Fraction IV, a discard fraction of the Cohn fractionation scheme, may be used as a supplement in cell growth media if the Fraction IV is rendered substantially free of components within the molecular weight range 2.5.times.10.sup.5 -1.0.times.10.sup.10, which components inhibit cell growth.

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Lafayette, CA, United States of America

Milton B Dobkin