Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Miloslav Polasek

Jan Kretschmer

Kelsea Grace Jones

Tomas David

Michal Straka

Adam Jaros

The present invention relates to compounds of general formula (I) for chromatographic separation of rare earth elements and/or s-, p-, d-metals, as well as to the method of the separation of rare earth elements.

Compounds for separation of rare earth elements and s-, p-, d-metals, method of separation, and use thereof

Cyclen based compounds of general formula (I) are disclosed. X is nitrogen and Y, Z are —CH—, or X, Z are —CH— and Y is nitrogen, or X, Y are —CH— and Z is nitrogen. Ris independently selected from H; COOH; benzyloxycarbonyl; fluorenylmethyloxycarbonyl; tert-butoxycarbonyl; methylcarbonyl; trifluoromethylcarbonyl; benzyl; triphenylmethyl; tosyl; mesyl; benzyloxymethyl; phenylsulfonyl; ethoxycarbonyl; 2,2,2-trichloroethyloxycarbonyl; methoxycarbonyl; methoxymethyloxycarbonyl; Ris selected from H; methylcarbonyl; tert-butyldimethylsilyl; (C1-C4)alkyl; Ris independently selected from H; (C1-C6)alkyl.

Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

The present invention relates to compounds of general formula (I), wherein —X is selected from a group consisting of H; Cto C, alkyl; halogen (F, Cl, Br or I); Y is selected from a group consisting of nitrogen; N-oxide; Z, Z, Z, wherein m is 1 or 2, are independently selected from the group consisting of —CH—CH— and —CH—CH—CH; A, A, wherein m is 1 or 2, are independently selected from H; —CHCOOH; —CHC(O)NH; —CHP(O)(OH), and n is 1 or 2; R, R, Rare independently H; Cto C, alkyl; Cto Calkyloxy; Cto Caryloxy; benzyloxy; Cto Calkylthio; C, to Carylthio; F; Cl; Br; I; OH; SH; NH; Cto C, alkylamino; di(Cto C, alkyl)amino; Cto Cacylamino; di(Cto Cacyl) amino; Cto Carylamino; di(Cto Caryl)amino; CN; OH; nitro; COOR, C(O)NHR, C(O)N(R), wherein Ris independently H or Cto Calkyl or C, to Caryl; and/or neighboring two of R, R, Rtogether with neighboring two carbon atoms of the aromatic cycle form a six-membered ring, optionally substituted with one or more substituents independently selected from the group consisting of OH, SH, CF, F, Cl, Br, I, Cto C, alkyl, Cto C, alkyloxy, Cto Calkylthio, NH, Cto Calkylamino, di(Cto Calkyl)amino, NO, COOH, COOR, C(O)NHR, C(O)N(R), wherein Ris WO 2020/244686 A1 independently H or Cto Calkyl or Cto Caryl; with the proviso that when n is 2 and all of Z, Z, Zare —CH—CH, then A is not —CHCOOH; for chromatographic separation of rare earth elements and/or s-, p- and d-block metals, as well as to the method of the separation of rare earth elements.

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Prague, Czechia

Miloslav Polasek