Northeastern University

Cireca Theranostics, LLC

Milos Miljkovic

Max Diem

Benjamin Bird

Melissa Romeo

Jennifer Schubert

Kostas Papamarkakis

Clay Matthew Thompson

Stanley H Remiszewski

A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.

Method for analyzing biological specimens by spectral imaging

Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed.

Phase correction to compensate for reflective distortions of optical spectra

Embodiments of the present disclosure provides improved methods for determining the presence of abnormalities in exfoliated cells. In one embodiment, the present disclosure provides methods for reconstructing cellular spectrum of a cell sample by creating a spectral map of the cellular sample, generating a binary mask of the spectral map, removing edge artifacts from each cell, and co-adding spectral data of each pixel corresponding to the cell to reconstruct the spectrum of each cell.

Method of reconstituting cellular spectra useful for detecting cellular disorders

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Jamaica Plain, MA, United States of America

Milos Miljkovic