Triton Algae Innovations, Inc.

University of California

The Scripps Research Institute

Miller Tran

Stephen P Mayfield

Beth Ann Rasala

Michael Mayfield

Xun Wang

Jon Hansen

Austin Hallgren

Robert McBride

Oscar Gonzalez

John Tzu-Yu Chang

Jeremy Ferrara

Provided herein are methods for the production of high density cultures of algae as well as nutritional supplements from such cultures and the use of such cultures to produce therapeutic proteins.

Method for growing algae

Provided herein are methods for the treatment of GI tract diseases and conditions and/or symptoms associated with such diseases and conditions in a mammal. Also provided are preparations and compositions for use in the methods. Also provided are methods of growing and preparingbiomass for administration to a mammal in need of treatment of GI tract diseases and conditions and/or symptoms associated with such diseases and conditions.

Method of treating alimentary canal conditions

Provided herein are methods for obtaining purified recombinant osteopontin (rOPN) from cultures of transgenic microalgae, as well as nutritional supplements from such cultures.

Method of purification of recombinant osteopontin from micro algae

Provided are colostrum and milk polypeptides recombinantly expressed in photosynthetic organisms containing colostrum and milk polypeptides, compositions comprising such organisms and methods for producing such organisms.

Colostrum/milk protein compositions

Provided are chloroplasts engineered to recombinantly express mammalian colostrum and milk polypeptides, photosynthetic organisms containing such chloroplasts, and compositions comprising such organisms and methods for producing such organisms. In certain embodiments, provided is a chloroplast comprising one or more polynucleotides encoding one or more mammalian milk or colostrum polypeptides selected from osteopontin, lactadherin, cathelicidin-1, lysozyme, lactoperoxidase, lingual antimicrobial peptide (LAP), alpha-lactalbumin, and soluble CD14.

Growing community of inventors

San Diego, CA, United States of America

Miller Tran