Pliva Hrvatska D.o.o.

Pliva D.d.

Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo

Miljenko Dumi&cacute;

Aleksandar Danilovski

Darko Fili&cacute;

Bozena Klepi&cacute;

Ines Fistri&cacute;

Marijan Tudja

Marina Ore{haeck Over (s)}i&cacute;

Jasna Horvat Mikul{haeck Over (c)}i&cacute;

Jasna Horvat Mikulci&cacute;

Marina Oresi&cacute;

The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.

Crystal modification of torasemide

The present invention relates to an amorphous torasemide modification, to a process for preparation thereof, to its use as a raw material for the preparation of pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the amorphous torasemide modification as well as to its use as a diuretic.

Amorphous torasemide modification

The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.

Growing community of inventors

Zagreb, Croatia

Miljenko Dumi&cacute;