Adare Pharmaceuticals USA, Inc.

Orbis Biosciences, Inc.

University of Kansas

Bayer Cropscience Gmbh

Bayer Aktiengesellschaft

Milind Singh

Cory Berkland

Michael S Detamore

David A Long

Malcolm Faers

Aaron M Scurto

William Hanson

Aveen Alkhatib

Anjan Das

Fred Rosa

Particles for delivery of active ingredients formed from an active ingredient and a hydrophobic matrix, as well as methods for making such particles.

Sustained release particle formulations

The present disclosure relates to the field of agrochemical compositions and formulations. In an aspect, the present disclosure provides for a composition in combination with a fibril or microfibril or nanofibril structuring agent. In yet another aspect, the disclosure provides for a composition comprising: (a) an agricultural bioactive material, a fungicide, insecticide, herbicide, and/or plant growth regulator; (b) a fibril or microfibril or nanofibril structuring agent; and (c) optionally, an auxiliary surface active agent. The disclosure further provides for a comprising a composition described herein mixed or combined with a liquid fertilizer.

Liquid fertilizer-dispersible compositions and methods thereof

The present disclosure relates to a taste-masking microcapsule composition. The composition comprises a core portion encapsulated by a shell portion. The core portion comprises an active pharmaceutical ingredient (API) and one or more excipients. The shell portion comprises a hydrophobic matrix and a pH-responsive material. The microcapsule compositions prevent API release at the more neutral pH levels in the oral cavity, but upon exposure to pH levels of the stomach, the pH-responsive material becomes soluble thereby permitting release of the API.

Taste masking drug formulations

Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.

Method of preparing a tissue engineering scaffold comprising a plurality of microspheres linked together

A tissue engineering scaffold for growing cells can include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.

Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals

Growing community of inventors

Mission, KS, United States of America

Milind Singh