Other

University of Toronto

Quthero, Inc.

Uti Limited Partnership

Milica Radisic

Boyang Zhang

Yimu Zhao

Nimalan Thavandiran

Yun Xiao

Sara Vasconcelos

Jason Miklas

Serena Mandla

Axel Guenther

Peter Zandstra

Lian Leng

William Michael Scott

Maria Ann Rupnick

Miles Montgomery

Locke Davenport Huyer

Holly Danielle Sparks

Qinghua Wu

Anastasia Korolj

Peter Backx

Naimeh Rafatian

Carol Laschinger

Jeffrey Alan Biernaskie

Andrew Wollard

Arianna McAllister

Susan Dallabrida

A composition for extrusion and deposition by a three-dimensional (3D) printer is provided. The composition comprises a thermoplastic elastomer (TPE), particulate matter having particles in the range of about 5 nm to about 10 μm in diameter, and a solvent. Uses of the composition for 3D printing microstructures, including multiwall plate devices, are also provided.

Thermoplastic polymer composition for micro 3D printing and uses thereof

The present disclosure provides ex vivo chamber-specific cardiac tissues, methods for generating the cardiac tissues in a bioreactor, and methods of using the cardiac tissues. Examples of cardiac tissues that can be generated include, but are not limited to, atrial tissues, ventricular tissues, and composite tissues having an atrial tissue connected to a ventricular tissue.

Methods for tissue generation

Compositions, formulations and methods of use thereof for treating, preventing and improving the condition and aesthetic appearance of skin are described. Compositions, formulations and methods of use thereof for treatment of dermis wounds, aged dermis, diseased dermis or damaged dermis are also described. The present compositions and formulations comprise a peptide with an amino acid sequence of QHREDGS (SEQ ID NO: 1) and methods of use thereof.

Compositions and methods of use for treatment or improvement of the condition and appearance of skin

The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

Methods for modeling disease tissue using three-dimensional tissue systems

The present invention examines the interaction between an angiopoietin-1 mimetic peptide, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine (SEQ ID NO: 1)) immobilized to a collagen-chitosan hydrogel, and murine bone marrow derived macrophages. When macrophages were cultured in the presence of the peptide conjugated to a hydrogel, both pro-inflammatory and anti-inflammatory cytokines were produced, in contrast to the application of soluble peptide which elicited minimal cytokine secretion. This indicates a unique macrophage polarization with covalently immobilized peptide hydrogels, which can be beneficial in the context of the wound microenvironment.

Q-peptide hydrogel promotes immune modulation and macrophage differentiation

A method of treating infection and/or inflammation in a subject includes steps of providing a polyester biomaterial comprising diol monomers and at least first carboxylate monomers, wherein the first carboxylate monomers are itaconate; and administering the polyester biomaterial to the subject. The polyester biomaterial can be in the form of a biomimetic, and characterized by hydrolytic degradability. The polyester biomaterial may further include second carboxylate monomers. The biomaterial can be poly(itaconate-co-citrate-co-octanediol).

Biomaterial comprising poly(itaconate-co-citrate-co-octanediol)

An apparatus for cultivation of cells, particularly podocytes, is described. The apparatus includes a cell cultivation surface exhibiting at least one feature providing a non-planar microtopology. A method for cultivation of cells, particularly podocytes, is also described. The method includes introducing a differentiation media including ATRA, Vit D3, and Dex.

Apparatus and method for high-fidelity podocyte cultivation

Compositions and methods for making and using three-dimensional tissue systems

Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.

Cardiac tissue constructs and methods of fabrication thereof

Methods and devices are disclosed for providing the controlled formation of planar homogeneous or heterogeneous materials using microfluidic devices. In one embodiment, a planar array of microfluidic channels is employed to produce a flowing liquid sheet having heterogeneous structure by spatially and temporally controlling dispensing of polymer liquid from selected microchannels. The resulting liquid sheet is solidified to produce a planar heterogeneous material that may be continuously drawn and/or fed from the plurality of microfluidic channels. The polymer liquid may include a payload that may be selectively incorporated into the heterogeneous structure. In some embodiments, the local material composition is controllable, thereby allowing control over local and bulk material properties, such as the permeability and the elasticity, and of creating materials with directionally dependent properties.

Devices and methods for producing planar polymeric materials using microfluidics

A peptide comprising the amino acid sequence, XXRXDXXXXis provided, as well as a biomaterial comprising the peptide for use to treat conditions resulting from cell death or apoptosis.

Cell-protective peptides and uses thereof

Growing community of inventors

Toronto, Canada

Milica Radisic