Daylight Solutions, Inc.

Miles James Weida

David F Arnone

Jeremy A Rowlette

Timothy Day

Edeline Fotheringham

William Chapman

Bruce H Coy

Michael B Pushkarsky

David P Caffey

Benjamin Bird

Eric Kim

Justin Kane

Russ Pritchett

David F Amone

Rudy Bermudez

Daniel Forster

An imaging microscope () for generating an image of a sample () comprises a beam source () that emits a temporally coherent illumination beam (), the illumination beam () including a plurality of rays that are directed at the sample (); an image sensor () that converts an optical image into an array of electronic signals; and an imaging lens assembly () that receives rays from the beam source () that are transmitted through the sample () and forms an image on the image sensor (). The imaging lens assembly () can further receive rays from the beam source () that are reflected off of the sample () and form a second image on the image sensor (). The imaging lens assembly () receives the rays from the sample () and forms the image on the image sensor () without splitting and recombining the rays.

Infrared imaging microscope using tunable laser radiation

A spectral imaging device () for capturing one or more, two-dimensional, spectral images (A) of a sample () including (i) an image sensor (), (ii) an illumination source (), (iii) a beam path adjuster (), and (iv) a control system (). The illumination source () that generates an illumination beam () that is directed along an incident sample beam path () at the sample (). The beam path adjuster () selectively adjusts the incident sample beam path (). The control system () controls (i) the illumination source () to generate the illumination beam during the first capture time, (ii) the image sensor () during the first capture time to capture first information for the first spectral image (A), and (iii) the beam path adjuster () to selectively adjust the incident sample beam path () relative to the sample () during the first capture time while the image sensor () is accumulating the information for the first spectral image (A).

Low-noise spectroscopic imaging system with steerable substantially coherent illumination

A flow cell assembly () for a fluid analyzer () that analyzes a sample () includes (i) a base () that includes a base window (B); (ii) a cap () having a cap window (B) that is spaced apart from the base window (B); and (iii) a gasket () that is secured to and positioned between the base () and the cap (), the gasket () having a gasket body (A) that includes a gasket opening (B). The gasket body (A), the base () and the cap () cooperate to define a flow cell chamber (). Moreover, an inlet passageway () extends into the flow cell chamber () to direct the sample () into the flow cell chamber (); and an outlet passageway () extends into the flow cell chamber () to allow the sample () to exit the flow cell chamber ().

Flow cell for direct absorption spectroscopy

A spectral imaging device () includes an image sensor (), a tunable light source (), an optical assembly (), and a control system (). The optical assembly () includes a first refractive element (A) and a second refractive element (B) that are spaced apart from one another by a first separation distance. The refractive elements (A) (B) have an element optical thickness and a Fourier space component of the optical frequency dependent transmittance function. Further, the element optical thickness of each refractive element (A) (B) and the first separation distance are set such that the Fourier space components of the optical frequency dependent transmittance function of each refractive element (A) (B) fall outside a Fourier space measurement passband.

Low-noise spectroscopic imaging system using substantially coherent illumination

A laser assembly () for generating a pulsed output beam () includes a quantum cascade device (); and a laser driver (A) that controls the voltage to the quantum cascade device () in a pulsed drive profile () to generate the pulsed output beam (). The pulsed drive profile () includes a plurality of spaced on-time segments () in which the laser driver (A) directs voltage to the quantum cascade device (), and at least one off-time segment () in which the laser driver (A) pulls down the voltage from the quantum cascade device (). The off-time segment () occurs between two on-time segments ().

Pulsed quantum cascade device assembly with active voltage pulldown

A method for identifying one or more analytes (A)(B)(C) includes (i) directing a solvent () into a test cell (); (ii) directing a first laser probe beam () at the solvent () in the test cell (); (iii) acquiring a solvent intensity spectrum of the solvent (); (iv) directing a sample () that includes one or more analytes (A)(B)(C) and the solvent () into the flow cell (); (v) directing a second laser probe beam () at the sample () in the test cell (); (vi) acquiring a sample intensity spectrum of the sample (); (vii) calculating a solvent referenced transmittance spectrum that details a solvent reference transmittance as a function of wavelength using the solvent intensity spectrum and the sample intensity spectrum; and (viii) identifying one or more analytes (A)(B)(C) in the sample () using the solvent referenced transmittance spectrum.

Trace chemical concentration measurement using mid-infrared absorption spectroscopy in a highly absorbing medium

A chromatography analyzer system () for analyzing a sample () includes a MIR analyzer () for spectrally analyzing a sample fraction (A) while the sample fraction (A) is flowing in the MIR analyzer (). The MIR analyzer () includes (i) a MIR flow cell (C) that receives the flowing sample fraction (A), (ii) a MIR laser source (A) that directs a MIR beam (B) in a MIR wavelength range at the sample fraction (A) in the MIR flow cell (C), and (iii) a MIR detector (D) that receives light from the sample fraction (A) in the MIR flow cell (C) and generates MIR data of the sample fraction (A) for a portion of the MIR wavelength range.

Liquid chromatography analyzer system with on-line analysis of eluting fractions

An assembly () for analyzing a sample () includes a detector assembly (); a tunable laser assembly (); and (iii) a laser controller (F). The detector assembly () has a linear response range () with an upper bound (A) and a lower bound (B). The tunable laser assembly () is tunable over a tunable range, and includes a gain medium (B) that generates an illumination beam () that is directed at the detector assembly (). The laser controller (F) dynamically adjusts a laser drive to the gain medium (B) so that the illumination beam () has a substantially constant optical power at the detector assembly () while the tunable laser assembly () is tuned over at least a portion of the tunable range.

Laser power adjustment during tuning to compensate for detector response and varying background absorption

A spectral imaging device () includes an image sensor (), an illumination source (), a refractive, optical element (A), a mover assembly (C) (), and a control system (). The image sensor () acquires data to construct a two-dimensional spectral image (A) during a data acquisition time (). The illumination source () generates an illumination beam () that illuminates the sample () to create a modified beam (I) that follows a beam path (B) from the sample () to the image sensor (). During the data acquisition time (), the control system () controls the illumination source () to generate the illumination beam (), and controls the image sensor () to capture the data. Further, during the data acquisition time (), an effective optical path segment () of the beam path (B) is modulated.

Low-noise spectroscopic imaging system

A laser source () that generates an output beam () that is directed along a beam axis (A) that is coaxial with a first axis and orthogonal to a second axis comprises a first frame (), a laser (), and a first mounting assembly (). The laser () generates the output beam () that is directed along the beam axis (A). The first mounting assembly () couples the laser () to the first frame (). The first mounting assembly () allows the laser () to expand and contract relative to the first frame () along the first axis and along the second axis, while maintaining alignment of the output beam () so the beam axis (A) is substantially coaxial with the first axis. The first mounting assembly () can include a first fastener assembly () that couples the laser () to the first frame (), and a first alignment assembly () that maintains alignment of the laser () along a first alignment axis () that is substantially parallel to the first axis.

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Poway, CA, United States of America

Miles James Weida