Delrx Pharmaceutical Corporation

Other

Mqs, Inc.

Miles Augustus Libbey, Iii

Randall Eugene McCoy

Robert O Williams, Iii

Jle Liu

The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed with a permeation enhancer and excipients which are dispersed in a media for oral or intranasal administration. Also provided in the present invention is a process to prepare the formulations.

Formulations for administering calcitonin and processes for preparing the same

A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device.

Formulation and system for intra-oral delivery of pharmaceutical agents

A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.

Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same

An optical system for the tracking or verification of items, having an energy source (e.g., an illumination source), selectively producing a specific wavelength (or small set of wavelengths, such as a spectrum) of energy matched with a material sensitive to that illumination. When the material is subjected to the energy source, it emits a wavelength of energy which is then sensed by a detector.

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Pennington, NJ, United States of America

Miles Augustus Libbey, Iii