Vilnius University

Milda Mickute

Saulius Klimasauskas

Giedrius Vilkaitis

Provided is a method for modifying a ssRNA at the 3' end, the method including contacting the strand with a ssRNA 2&#x2032;-O-methyltransferase in the presence of a co-factor, under conditions which allow for the transfer by the ssRNA 2&#x2032;-O-methyltransferase of a part of the co-factor onto the 3&#x2032; end of the ssRNA to form a modified ssRNA, wherein the ssRNA bears 2&#x2032;-OH group at 3&#x2032; terminal nucleotide and wherein the part of the co-factor transferred includes a reporter group or a functional group.

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Vilnius, Lithuania

Milda Mickute