Eli Lilly and Company

Milata Mary Abraham

Hongchang Qu

Jorge Alsina-Fernandez

Tamer Coskun

James Lincoln Wallis

John Lee

Lili Guo

Robert Chadwick Cummins

Daniel Anthony Briere

Samantha Grace Lyons Keyser

Robert Andrew Brown

Over Cabrera

Mohamed ElSayed Hamed Elsayed

Amita Datta-Mannan

Xianyin Lai

Incretin analogs are provided that have activity at each of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors. The incretin analogs have structural features resulting in balanced activity and extended duration of action at each of these receptors. Methods also are provided for treating diseases such as type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and obesity.

Incretin analogs and uses thereof

The present disclosure relates to the field of medicine. More particularly, the disclosure is in the field of treatment of diabetes, obesity and/or chronic weight management, dyslipidemia and/or NASH. The disclosure relates to compounds that agonize the amylin receptor and can lower food intake, body weight, glucose and/or triglycerides, so can be used to treat diabetes, obesity, and/or dyslipidemia. The present disclosure also includes pharmaceutical compositions containing such compounds and therapeutic uses of such compounds and compositions.

Long acting amylin receptor agonists and uses thereof

The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus ('T2DM'). Also, the compounds may be useful in the treatment of obesity.

GIP/GLP1 co-agonist compounds

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Indianapolis, IN, United States of America

Milata Mary Abraham