Fyzikalni Ustav Av Cr, V.v.i.

Ustav Makromolekularni Chemie Av Cr, V.v.i.

Ustav Fotoniky a Elektroniky Av Cr, V.v.i.

Milan Houska

Hana Lisalova

Jiri Homola

Tomas Riedel

Marketa Vrabcova

Alexandr Dejneka

Frantisek Surman

Cesar Rodriguez-Emmenegger

Eduard Brynda

Ivana Visova

A random terpolymer of N-(2-hydroxypropyl) methacrylamide, carboxybetaine methacrylamide and sulfobetaine methacrylamide, and a polymer brush and to a functionalized polymer brush containing this terpolymer are disclosed. The random terpolymer increases the resistance of the substrate surface to non-specific adsorption of substances from biological media and/or to non-specific interaction with biological media components, and is suitable for use in the form of a polymer brush, for example in sensors or membranes.

Terpolymer and polymer brushes for use against non-specific adsorption of substances from biological media

The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure IS&#x2014;R-polymer&#x2003;&#x2003;(I) Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine metacrylamide, polymer brushes

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Prague, Czechia

Milan Houska