Ceskoslovenska Akademie Ved

Milan Benes

Jan Peska

Jiri Coupek

Jiri Stamberg

Frantisek Svec

Zedenek Plichta

Jiri Lenfeld

The invention pertains to a method for the production of bead dextran materials for gel chromatography. The subject of the invention is a method for the production of bead dextran materials for gel chromatography, wherein dextran is, before or during the suspension process or in both stages, subjected to reduction in an alkaline solution, advantageously by the action of sodium borohydride, whereas the density of crosslinking is controlled above all by variation of the concentration of the initial dextran solution and the resulting gel may be optionally subjected to the additional crosslinking in a separate subsequent operation. The procedure according to the invention provides the product of higher quality with a lower content of carboxylic groups and substantially facilitates the preparation of gels with a very high and a very low crosslink density.

Method for the production of bead dextran materials for gel

The invention relates to quaternary cationic monomers and polymers and copolymers prepared thereof, based upon salts of methacrylic or acrylic esters of the general formula I ##STR1## where R.sup.1 is H or CH.sub.3

Quaternary salts of methacrylic or acrylic esters and cationic

Quaternary salts of methacrylic or acrylic esters

Quaternary salts of methacrylic or acrylic esters and cationic quaternay

The invention relates to chemically reactive polymers and copolymers of hydroxyalkyl methacrylate sulfo esters with monomer units of the formula ##EQU1## where n is an integer equal to 1 or 2 and R is C.sub.6 H.sub.5 --, p--CH.sub.3 C.sub.6 H.sub.4 --, or CH.sub.3 -- and to the method of manufacturing the technically useful articles from these polymers, namely crosslinked beads, membranes, blocks, etc., by free-radical polymerization or copolymerization in bulk, solution or in two-phase aqueous dispersion system under conditions whereby the hydrolysis of the sulfo ester is suppressed.

Polymers and copolymers of hydroxyalkyl methacrylate sulfo esters and

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Milan Benes