Egis Gyogyszergyar Rt.

Miklós Végh

Gyula Simig

Gábor Szénási

Gabor Gigler

Jozsef Barkoczy

József Barkóczy

Zoltán Greff

György Lévay

Istvan Ling

Gábor Gigler

László Gábor Hársing

Szabolcs Kertesz

Bernadett Martonné Markó

Geza Szabo

Laszlo Gabor Harsing

István Ling

Géza Szabó

Gyula Szücs

Zoltán Rátkai

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula &#x2014;NH&#x2014;R', wherein R&#x2032; stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity. 

8-chloro-2,3-benzodiazepine derivatives

The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a Calkyl group or a group of the formula &#x2014;NRR, wherein Rand Rrepresent, independently, a hydrogen atom, a Calkyl group, a Calkoxy group or a Ccycloalkyl group. 

2, 3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

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Miklós Végh