Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Biochin Biotechnologial Leanyvallalat

Miklos Jarai

Sandor Piukovich

Istvan Gado

Sandor Istvan

Istvan Barta

Valeria Szell

Antonia Jekkel Nee Bokany

Jozsef Szejtli

Gyorgy Szvoboda

Gabor Seres

Ilona Varga

Marta Szoke Nee Zlatos

Mariann Nagy

Istvan Financsek

Gy Uml/o/ Szvoboda

Viola Muri

Laszlo Kegl

Maria Szigetvari Nee Gabanyi

Andrasi Andras

Endre Kollar

Geza Kocsis

Gabriella Zlatos

Mihaly Garamvolgyi

A/ Gnes Udvardy

Process for the preparation of vancomycin

The invention relates to a process for the preparation of high-purity gamma- and alpha-cyclodextrin starting from a starch substrate of low reducing capacity, partially hydrolysed with alpha-amylase. According to the invention a starch substrate of low reducing capacity partially hydrolysed with alpha-amylase is converted with cyclodextrin glucosyl transferase, after the addition of an aliphatic ketone of the formula R.sub.1 COR.sub.2, in which R.sub.1 and R.sub.2 stand for a straight or branched chained alkyl group having from 1 to 6 carbon atoms, and/or a phenol derivative of the formula R.sub.3 R.sub.4 PheOH, wherein R.sub.3 and R.sub.4 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together form phenyl group, Phe stand for phenyl group, OH is hydroxyl and/or a benzene derivative of the formula R.sub.5 R.sub.6 Phe, wherein R.sub.5 and R.sub.6 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.5 and R.sub.6 together form phenyl group, Phe is phenyl, as a precipitating agent, and if desired, alpha- and/or gamma-cyclodextrin is isolated from the conversion mixture in a crude form, or after further purification, in a pure form.

Process for the preparation of high-purity gamma- and alpha-cyclodextrins

Micromonospora danubiensis, a new species, having the capability of producing sisomicin.

Micromonospora culture

Sisomicin is produced by culturing Micromonospora danubienis.

Method for the production of sisomicin

A process of producing sisomycin by cultivating a new species of Micromonospora.

Method for the preparation of antibiotic sisomicin

A culture of Micromonospora rosea capable of producing the antibiotic sisomicin.

Growing community of inventors

Budapest, Hungary

Miklos Jarai