Instrumentation Laboratory Company

Miklos Erdosy

Prasad Pamidi

Vasile Cosofret

Xiaoxian Xu

David Raimondi

Hyoungsik Yim

Prasad V A Pamidi

Emily McDowell

Techniques includes measuring, using a creatine sensor, a creatine sensor current signal (ΔI2) of a first calibration solution (CS2). A creatine sensor sensitivity (Slope) for the creatine sensor is based on the creatine sensor current signal (ΔI2). The first calibration solution (CS2) has a known concentration of creatine (CR_CS2), a known concentration of creatinine (CREA_CS2), and a stable ratio of creatine to creatinine over a range of temperatures for a predefined shelf-life of the first calibration solution (CS2). The Techniques include measuring, using the creatine sensor, a measured creatine concentration (MCR_CS3) of a second calibration solution (CS3). The second calibration solution (CS3) has an initial known creatine concentration (CR_CS3), an initial known creatinine concentration (CREA_CS3), and an unstable ratio of creatine to creatinine that changes over the predefined shelf-life. Concentrations of creatine and creatinine in a sample are thereafter estimated.

Compositions and methods for improved calibration accuracy of creatinine/creatine sensors and uses thereof

An example blood cell lysis composition includes a buffer and a secondary alcohol ethoxylate at a concentration in the range of about 2.5 percent (%) to about 20% weight per volume (w/v). The secondary alcohol ethoxylate may include Tergitol™ TMN-100X or Tergitol™ 15-S-9. The composition may be configured to lyse at least 90% of blood cells in a blood sample.

Blood cell lysis compositions and uses thereof

The invention relates to a durable and reliable miniature liquid junction reference electrode for use with at least one electrode (e.g., an electrochemical sensor cartridge) for measuring certain characteristics of a fluid sample such as blood or other body fluid.

Liquid junction reference electrode and methods of use thereof

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North Chelmsford, MA, United States of America

Miklos Erdosy