Nuevolution A/s

Nanocore Aps

Neuvolution A/s

Mikkel Dybro Lundorf

Henrik Pedersen

Per-Ola Freskgard

Alex Haahr Gouliaev

Jakob Felding

Thomas Franch

Christian Klarner Sams

Anette Holtmann

Eva Kampmann Olsen

Kim Birkebaek Jensen

Soeren Nyboe Jakobsen

Thomas Thisted

Sanne Schrøder Glad

Sanne Schroeder Glad

Tore Dehli

Michael Anders Godskesen

Mads Nørregaard-Madsen

Gitte Nystrup Husemoen

Søren Neve

Tine Titilola Akinleminu Kronborg

Johannes Dolberg

Frank Abildgaard Sløk

Ditte Kievsmose Kaldor

Daen De Leon

Anne Goldbech

Anders Malling Sørensen

Anders Holm Hansen

Anne Lee Andersen

Sanne Schroder Glad

Søren Nyboe Jakobsen

Kim Birkebæk Jensen

Torben Ravn Rasmussen

Lene Petersen

Per-Ola Freskgård

Frank Abilgaard Sløk

Christian Benedikt Nielsen

Sanne Birkebaek Jensen

Kim Birkebæ Jensen

Søren Nyboe Jacobsen

Lene Pedersen

Per-Ola Freskgaard

Per-Ola Freskaard

Soren Nyboe Jakobsen

Søren Jakobsen

Ditte Kivsmose Kaldor

Birgitte Nystrup Husemoen

Christiam Klarner Sams

Tine Titiola Akinleminu Kronberg

Dean De Leon

Alex Haahr Goliaev

Anders Malling SØRENSEN

Per-Ola FRESKGÅRD

Tine Titilola Akinleminu Kronberg

Christian Benedikt Orea Nielsen

Composite material units (CMU) of the structure (SE1-ML-LinkerL-Ligand2-SE2), are provided, wherein ML is a Mechanical Ligand, LinkerL is a chemical bond or entity that covalently links ML and Ligand2, Ligand2 is a chemical entity that is covalently linked to the structural entity SE2, or forms a mechanical bond with the structural entity SE2, and SE1 and SE2 are structural entities.

Composite materials comprising mechanical ligands

In one aspect, the present invention relates to a method for obtaining structural information about an encoded molecule. The encoded molecule may be produced by a reaction of a plurality of chemical entities and may be capable of being connected to an identifier oligonucleotide containing codons informative of the identity of the chemical entities which have participated in the formation of the encoded molecule. In a certain embodiment, primers are designed complementary to the codons appearing on the identifier oligonucleotide, and the presence, absence or relative abundance of a codon is evaluated by mixing a primer with the identifier oligonucleotide in the presence of a polymerase and substrate (deoxy)ribonucleotide triphosphates measuring the extension reaction. In another aspect, the invention provides a method for selecting compounds which binds to a target. More specifically, the invention relates to a method in which a target associated with an oligonucleotide initially is mixed with a library of complexes, each complex comprising a display molecule and an oligonucleotide identifying said display molecule. Next, due an increased proximity, the target oligonucleotide is coupled to the identifier oligonucleotide of complexes having a display molecule with affinity towards the target. In a final stage the coupled nucleotides are analyzed to deduce at least the identity of the display molecule.

Method for obtaining structural information concerning an encoded molecule and method for selecting compounds

A type of composite material where the matrix material and additive are held together by covalently or non-covalently bound ligands is described. A particularly useful composite material covered by the present invention is a carbon nanotube-reinforced composite material where the matrix consists of a polymer, covalently attached to a linker, where said linker is non-covalently attached to the carbon nanotube. Methods for the preparation of such composite materials are provided.

Composite materials with desired characteristics

Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

Enzymatic encoding methods for efficient synthesis of large libraries

In one aspect, the present invention relates to a method for obtaining structural information about an encoded molecule. The encoded molecule may be produced by a reaction of a plurality of chemical entities and may be capable of being connected to an identifier oligonucleotide containing codons informative of the identity of the chemical entities which have participated in the formation of the encoded molecule. In a certain embodiment, primers are designed complementary to the codons appearing on the identifier oligonucleotide, and the presence, absence or relative abundance of a codon is evaluated by mixing a primer with the identifier oligonucleotide in the presence of a polymerase and substrate (deoxy)ribonucleotide triphosphates and measuring the extension reaction. In another aspect, the invention provides a method for selecting compounds which binds to a target. More specifically, the invention relates to a method in which a target associated with an oligonucleotide initially is mixed with a library of complexes, each complex comprising a display molecule and an oligonucleotide identifying said display molecule. Next, due an increased proximity, the target oligonucleotide is coupled to the identifier oligonucleotide of complexes having a display mole-cute with affinity towards the target. In a final stage the coupled nucleotides are analysed to deduce at least the identity of the display molecule.

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.

Method for the synthesis of a bifunctional complex

Composite material, where the matrix material and the additive are held together by covalently or non-covalently bound ligands. The linker unit between matrix and additive has the structure Ligand1-LinkerL-Ligand 2, wherein Ligand1 and Ligand2 are a bond or a chemical entity that is capable of binding covalently or non-covalently to a structural entity, such as a polymer matrix or the additive (ex. CNT, graphene, carbon nanofiber, etc), and LinkerL is a chemical bond or entity that links Ligand1 and Ligand2.

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.

Growing community of inventors

Copenhagen, Denmark

Mikkel Dybro Lundorf