Eisai Company, Limited

Mikio Tomimatsu

Shigeru Souda

Shigeto Negi

Kazutoshi Miyake

Masayuki Matsukura

Toshiaki Ogawa

Naoki Yoneda

Yoshiharu Daiku

Kenichi Nomoto

Masanori Mizuno

Makoto Kaino

Tadanobu Takamura

Naoya Kishi

Koichi Nose

Fusayo Yoshida

Keizoh Satoh

Propenoic acid derivatives of the formula: ##STR1## where R.sup.15 and R.sup.17 are aryl or heteroalkyl groups and R.sup.16 and R.sup.18 are hydrogen, a lower alkyl or the like are intermediates used to prepare pharmaceutically active diazole propenoic acid compounds.

Diazole-propenoic acid compounds

A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I): ##STR1## (wherein A represents an aromatic ring; R.sup.1 represents aryl or the like; R.sup.2, R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like; and R.sup.7 and R.sup.8 each represent lower alkyl or the like) or a pharmacologically acceptable salt thereof.

Propenoic acid derivatives diazole propenoic acid compounds which have

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Mikio Tomimatsu