Kaneka Corporation

Other

Kanegafuchi Chemical Industry Co., Ltd.

Mikio Kitahara

Tatsumasa Mae

Kaku Nakagawa

Misuzu Tsukagawa

Kozo Yamamoto

Yoshihide Fuse

Souichi Morikawa

Yutaka Sashida

Yoshihiro Mimaki

Minpei Kuroda

Shin-ichi Yokota

Yasuyoshi Ueda

Shiro Kitamura

Hideyuki Kishida

Mitsuaki Kitano

Takashi Koyama

Norio Sugiura

Kiyoshi Watanabe

Takaaki Maekawa

Kazuhiro Nagata

Hajime Kawaharada

Syuichi Oka

Toshinori Ikehara

Shinichi Yokota

Hiroko Isoda

Kiyoto Ishii

Yuhei Inamori

Masako Tasaki

A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Compositions for preventing or ameliorating multiple risk factor syndromes

The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

Peroxisome proliferator activated receptor ligand and process for producing the same

In the present invention, an oil and fat composition containing 10% by weight or more of a specific fat-soluble polyhydric fatty acid ester, in particular, a glycerol fatty acid ester, is used as a solvent for extracting hydrophobic components from licorice. Consequently, it is possible to reduce the production costs for hydrophobic components of licorice which have excellent effects as food and drink, such as health food and food with health claims (food for specified health uses and food with nutrient function claims), pharmaceutical products, etc. It is also possible to improve the stability and handling properties of the resulting composition.

Process for producing fat composition containing hydrophobic components of glycyrrhiza

The object of the present invention is to provide PPAR&#x3b3; ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPAR&#x3b3; ligand as an active agent. The present invention relates to a ligand for peroxisome proliferator-activated receptor The composition according to the present invention, which comprises the PPAR&#x3b3; ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

Ligand for peroxisome proliferator-activated receptor

A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

Methods of treating cancer using a heat shock factor activity inhibitor

The present invention provides a bioassay system, for detection of hazardous chemical substances, natural toxic substances in the environment and unknown toxic compounds, with high sensitivity, simplicity and speed. The invention provides cells and a method of using the cells for use in the bioassay system. The cell provided by the invention contains a heat shock factor binding DNA sequence and a transcriptional regulatory sequence necessary on an occasion of stress induction as a transcriptional regulatory factor binding site. The cell also possesses a reporter gene under the control of the promoter. The reporter gene is connected, on the downstream side, to the SV40pA signal without any intervening intron.

High-sensitive detection of environmental pollutants

Heat shock factor activity inhibitor

Heat shock factor activity inhibitors

Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom or hydroxy, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.

7-hydroxyguanine compounds, process for preparing said compounds, and

Growing community of inventors

Kobe, Japan

Mikio Kitahara