Toyama Chemical Co., Ltd.

Mikio Kawabata

Yasuyuki Suzuki

Noboru Takagawa

Isamu Saikawa

Yasuo Kiba

Hiroshi Hirano

Shiro Hirai

Takuya Kodama

Akiko Takagi

Takako Wakamiya

Tatsuya Miyaura

Mariko Hayashi

The process for producing bischoline-disulfonate derivatives of Formula (I) ##STR1## useful for enhancing the digestive function comprising reacting, in the presence of an organic solvent, a trimethylammonium salt derivative of Formula (II) ##STR2## wherein R.sup.1 and R.sup.2 are individually lower alkyl and X is a group removable by a disulfonic acid of Formula (III)

Novel process for producing bischoline-disulfonate derivatives

This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, represents a hydrogen atom or a substituted or unsubstituted alkyl, cycloalkyl, alkenyl or aralkyl group, or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, when taken together with the respective adjacent nitrogen atoms, form a substituted or unsubstituted heterocyclic group; R.sup.5 represents a substituted or unsubstituted cycloalkyl, acyl or heterocyclic group; A represents a bond or a substituted or unsubstituted alkylene, alkenylene or alkadienylene group; and n is 1, 2 or 3. Said compound has an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such a compound, to a process for the production thereof and to an anti-ulcer agent containing the same.

N-acyl acidic amino acid diamide derivative, a salt thereof, and an

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Toyama, Japan

Mikio Kawabata