Taiho Pharmaceutical Company Limited

Maruko Seiyaku Co., Ltd.

Takeda Chemical Industries, Inc.

Wako Pure Chemical Industries, Inc.

Sanwa Kagaku Kenkyusho Co., Ltd.

Mikio Hori

Mitsugi Yasumoto

Hajime Fujimura

Akihide Koda

Ichiro Yamawaki

Yuji Yamada

Katsuo Takikawa

Yukio Tada

Sachio Ohno

Mitsuaki Nagasaka

Naosuke Matsuura

Kenji Miura

Yutaka Baba

Kiyoshi Mizukoshi

Noriyuki Iwata

Hajimu Yamamoto

Masatoshi Ban

Kazuo Kato

Yoshiki Nakamura

Shuichi Ueda

Kihachiro Izumi

Osamu Ootani

Akira Fukui

Tadashi Kitamikado

Eiichi Suenaga

Kiyoshi Kato

This invention provides an amide compound represented by the formula ##STR1## wherein R.sub.1 is vinyl, 2-(methylsulfinyl)ethyl, 2-(methylsulfonyl)ethyl, 2-(2-acetylamino-2-carboxyethylthio)ethyl or 2-[2-(4-amino-4-carboxybutyrylamino)-2-(carboxymethylcarbamoyl)ethylthio]e thyl and R.sub.2 is hydrogen or lower alkyl, process for the preparation thereof, and antiallergic compositions cotaining the amide compound.

Amide compounds

Sulfonium compounds represented by the formula ##STR1## having immunostimulant activity and useful as the active components of drugs and agricultural chemicals.

Sulfonium compounds

This invention provides novel sulfonium compounds, processes for the preparation of the sulfonium compounds, and pharmacological composition containing the sulfonium compound. The compounds of this invention are useful for treating allergy.

Sulfonium compounds, processes for preparing the compounds and

A method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benz azocines represented by general formula (I) below ##STR1## wherein R represents an alkyl group, a phenyl group or a heterocyclic group, which comprises reacting 1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benzazocine represented by the formula (II) below ##STR2## or its salt with chlorosulfonic acid, heating the reaction product in the presence of a reducing agent, and reacting the reaction mixture with an acyl halide represented by the general formula (III)

Method for preparing

A 2,5-benzodiazocine derivative represented by a formula ##STR1## wherein R.sub.1 is phenyl or p-methoxyphenyl, R.sub.2 is hydrogen or methyl, and R.sub.3 is p-methoxyphenethyl, 3-(p-fluorobenzoyl)-propyl, cyclopropylmethyl or ##STR2## or a salt of such novel compound as well as a CNS-active pharmaceutical agent containing as an effective component at least one of said derivatives and salts.

2,5-Benzodiazocine derivatives and salts thereof, as well as

Sulfonium compounds represented by the formula ##STR1## have anticancer activity, immunostimulant activity and the like, and useful as the active components of drugs and agricultural chemicals.

This invention relates to a pharmaceutical use of 3-oxo-2,3-dihydro[1]benzothiophene-2-spirocyclopropane. The compound exhibits strong inhibition activity of thrombocyte aggregation in mammalian blood. The compound and its pharmaceutical composition are useful for the prophylaxis or treatment of cardiovascular disturbance such as thrombosis.

Composition and method for inhibiting platelet aggregation

Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R.sub.2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and antispasmodic agents in mammals, and a process for preparing the same.

1,5-Benzothiazepine compounds

Pyrazole derivatives represented by the formula ##SPC1## Wherein R, X, R.sub.2 and R.sub.3 are hereinafter defined, which are useful as analgesics and anti-inflammatory agents and a process for preparing the pyrazole derivatives are disclosed.

Pyrazole derivatives and process for preparing the same

Growing community of inventors

Gifu, Japan

Mikio Hori