Other

Sekisui Chemical Co., Ltd.

Mikimoto Kanazashi

Kazuhiro Gomi

Makoto Fukae

Shinichiro Oida

Ayako Kakegawa

Yu Nagahara

Takaya Oshita

Tsuyoshi Uehara

Yoshishige Takikawa

Takatoshi Nagano

Takako Tanabe

Hiroaki Aiba

Yukiko Tanabe, Legal Representative

Akira Morooka

A plasma generating apparatus including: a plasma generating unit including a tubular dielectric to which an atmospheric pressure plasma generation gas is introduced, an inner electrode extending in a hollow portion of the tubular dielectric in axial direction of the tubular dielectric and having a coil shape or an irregular surface, and an outer electrode provided on the outside of the tubular dielectric, the inner electrode and the outer electrode being positioned opposite to each other through the tubular dielectric; and a discharge port for discharging an active gas containing active species generated by the atmospheric pressure plasma generated in the plasma generating unit.

Plasma generating apparatus, therapeutic method, and method for activating cell or living tissue

The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a part of periodontal regeneration, was examined by using experimental cavities prepared in a buccal dehiscence dog model. The CR activity was found in the aggregate consisted of sheath proteins along with a small amount of amelogenins separated from newly formed secretory enamel. The sheath proteins were purified to be homogeneous, and examined for the alkaline phosphatase (ALP) inducing activity of human periodontal ligament (HPDL) cells. Application of 17 kDa sheath protein induced ALP activity in HPDL cells. Peptides synthesized from the sheath protein sequence also showed ALP inducing activity. The 17 kDa sheath protein has cell differentiation activity.

Effect of porcine sheath proteins on the regeneration activity of periodontal ligament

Growing community of inventors

Yokohama, Japan

Mikimoto Kanazashi