Ajinomoto Co., Ltd.

Mikiko Yamaguchi

Hisao Ito

Hisashi Yasueda

Jun Nakamura

Seiko Hirano

Yoshiya Gunji

L-Arginine is produced by culturing a microorganism which has L-arginine producing ability and has been modified so that expression of lysE gene should be enhanced, such a microorganism further modified so that an arginine repressor should not function normally, or such a microorganism further modified so that intracellular activity of an enzyme in L-arginine biosynthetic pathway should be enhanced in a medium to produce and accumulate L-arginine in the medium and collecting the L-arginine from the medium.

Method for producing L-arginine

A coryneform bacterium which has an L-glutamic acid-producing ability and grows at least at the same growth rate as a non-mutated strain or a wild-type strain and has intracellular &#x3b1;-ketoglutarate dehydrogenase activity which is less than half that of the non-mutated or wild-type strain, and is obtained by introducing a mutation into a coding region or an expression control region of the chromosomal odhA gene encoding the E1o subunit of the &#x3b1;-ketoglutarate dehydrogenase complex.

Growing community of inventors

Kawasaki, Japan

Mikiko Yamaguchi