Canon Kabushiki Kaisha

Miki Ogawa

Hirokatsu Miyata

Takeshi Imamura

Akira Kuriyama

Tohru Den

Kazuhiko Fukutani

Norihiko Utsunomiya

Hiroshi Okura

Albrecht Otto

Yoichiro Handa

Junta Yamamichi

Satoru Nishiuma

Koichi Sato

Shinichi Nakamura

Kazuharu Katagiri

Yukio Hanyu

Takashi Ikeda

Hidemasa Mizutani

Ikuo Nakazawa

Tsuyoshi Nomoto

Manabu Komatsu

Masayuki Ikegami

Hidenori Shiotsuka

Hiroyuki Hashimoto

Masato Minami

Kazumichi Nakahama

Yasuhiro Kawashima

Yohei Murayama

Kazuhiro Ban

Tetsunori Ojima

Tomonari Horikiri

Norihhiko Utsunomiya

A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.

Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis

A microcolumnar structured material having a desired material. The columnar structured material includes columnar members obtained by introducing a filler into columnar holes formed in a porous material. The porous material has the columnar holes formed by removing columnar substances from a structured material in which the columnar substances containing a first component are dispersed in a matrix member containing a second component capable of forming a eutectic with the first component. The matrix member may be removed. In the columnar structured material, the filler is a conductive material, and an electrode can be structured by electrically connecting the conductive materials in at least a part of a plurality of holes to a conductor.

Method for producing columnar structured material

A chemical sensor that utilizes localized surface Plasmon resonance including a substrate, metal-containing particles and dielectric particles, wherein the metal-containing particles and the dielectric particles are disposed on the substrate, is used as a chemical sensor element. Thereby, a chemical sensor element having a sufficient detecting sensitivity when localized surface Plasmon resonance is utilized, and a method for the fabrication thereof, can be provided.

Method for fabricating chemical sensor element

A detecting element used for a detecting device for detecting a target substance in a sample by utilizing plasmon resonance. The detecting element includes a substrate and a plurality of metal members provided on the substrate, the metal member constituting a columnar structure and being oriented in a long axis direction thereof. The detecting element can improve sensitivity of the detecting device for detecting a target substance utilizing plasmon resonance.

Detecting element, and target substance detecting device and method of detecting target substance using the same

A detecting element for detecting a target substance in a sample includes a substrate having a pore, in which a thickness direction of the substrate corresponds to a depth direction of the pore, and plurality of metal structures disposed in the pore. The plurality of metal structures have a ring shape.

Detecting element, detecting device, and method of producing the detecting element

A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

Recognition chip for target substance, and detection method and device for the same

The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential &#x3c8;of the magnetic label in the sample solution, the surface potential &#x3c8;of the detecting parts and the surface potential &#x3c8;of the non-detecting part satisfy any one of the following relationships i) to iv):

Method for detecting target substance and target-substance detection kit

There is provided a detection apparatus detecting target substance in a sample by utilizing plasmon resonance including a substrate and a plurality of metal-containing members arranged on the substrate, wherein the metal-containing members are shaped tubular and the metal-containing members are arranged on the substrate with a given orientation. By use hereof, a detection apparatus and a detection method enabling highly sensitive detection on target substance are provided.

Detection element, detection apparatus for detecting target substance, method of detecting target substance and metal-containing member

The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.

Organic material-immobiling structure and method for production of the same, and peptide and DNA therefor

A method of manufacturing a dot pattern includes the steps of preparing a structured material composed of a plurality of columnar members containing a first component and a region containing a second component different from the first component surrounding the columnar members, with the structured material being formed by depositing the first component and the second component on a substrate, and removing the columnar members from the structured material to form a porous material having a columnar hole. In addition, a material is introduced into the columnar hole portions of the porous material to form a dot pattern, and the porous material is removed.

Columnar structured material and method of manufacturing the same

A structured material characterized in having, on a substrate, a layer having tubular pores positioned uniaxially parallel to the interface of the substrate and the layer and supporting a conductive polymer material having a function of a surfactant therein. A method for producing the above structure material characterized by the steps of providing a substrate having the anisotropy on a surface, applying a solution containing a surfactant having a functional group for polymerization in the molecular structure, a solvent therefor, and a solute different from the surfactant to the substrate, and a step of standing for a predetermined time for causing the surfactant to assemble in a predetermined direction based on the anisotropy of the substrate.

Structured material and producing method thereof

A method of producing a sensing element used in a detecting device for detecting a target substance in a specimen with the use of plasmon resonance. The method includes the steps of forming an insulating layer on a substrate, the surface of the substrate having an electroconductive layer including a first electroconductive material, forming a plurality of holes through the insulating layer to form an insulating pattern, filling up the holes with a second electroconductive material to form a metallic pattern, removing the insulating pattern, and removing a region other than the region sandwiched by the metallic pattern and the substrate in the electroconductive layer, using the metallic pattern as a mask.

Sensing element used in sensing device for sensing target substance in specimen by using plasmon resonance

A method of manufacturing a dot pattern includes the steps of preparing a structured material composed of a plurality of columnar members containing a first component and a region containing a second component different from the first component surrounding the columnar members, with the structured material being formed by depositing the first component and the second component on a substrate, and removing the columnar members from the structured material to form a porous material having a columnar hole. Additional steps include introducing a mask material into the columnar hole of the porous material to form a dot pattern, and removing the porous material.

A semiconductor device array comprising highly densely arranged nano-size semiconductor devices is prepared by a simple method. The array comprises a porous body having cylinder-shaped pores formed by removing cylinder-shaped regions from a structure that includes a matrix member formed so as to contain silicon or germanium and the cylinder-shaped regions containing aluminum and dispersed in the matrix member, semiconductor regions formed in the pores, each having at least a p-n or p-i-n junction, and a pair or electrodes, arranged respectively on the top and at the bottom of the semiconductor regions. The semiconductor regions and the pair of electrodes form a plurality of semiconductor devices on a substrate.

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Machida, Japan

Miki Ogawa