Nihon Medi-Physics Company, Limited

Miki Kurami

Nobuo Ueda

Komei Washino

Makoto Azuma

Susumu Kondo

Keietsu Takahashi

Yoshifumi Shirakami

A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10,

Diethylenetriamine pentaacetic acid derivatives

A high molecular compound useful as a non-radioactive carrier, which comprises at least one unit of (1) an asialoglycoprotein acceptor-directing compound and at least one unit of (2) a chelate-forming compound chemically bonded thereto, and which may be labeled with a radioactive metallic element to give a radioactive metallic element-labeled product useful as a radioactive diagnostic or therapeutic agent for liver.

Radioactive metallic element-labelled high molecular compound useful in

A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10, A' is a bivalent linking group formed by reacting both the reactive groups of a cross linking reagent, and

Asialoglycoprotein acceptor-directing compound having chelateforming

Radio labeled high molecular compound comprising unit of

A radioactive diagnostic or therapeutic agent, which comprises a metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic elements, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each of the radioactive metallic element (4) being chelate-bonded to the chelate-forming compound (2).

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Chiba, Japan

Miki Kurami