Mitsubishi Tanabe Pharma Corporation

Shanghai Pharmaceuticals Holding Co., Ltd.

Miki Hirai

Jingkang Shen

Toru Iijima

Guangxin Xia

Hiroshi Sugama

Takayuki Kawaguchi

Jianshu Xie

Yoichi Takahashi

Huixin Wan

Yasuyuki Tsuzuki

Yuko Togashi

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]: wherein Ris a cycloalkyl group and the like, Ris an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is &#x2014;O&#x2014; and the like, and Rto Rare the same or different and a hydrogen atom and the like; or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.

Nitrogen-containing saturated heterocyclic compound

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein Ris a cycloalkyl group or an alkyl,

Renin inhibitor

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]: wherein Ris a cycloalkyl group and the like, Ris an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is &#x2014;O&#x2014; and the like, and Rto Rare the same or different and a hydrogen atom and the like;or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.

A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; Ris independently halogen, cyano, etc., each of X, Xand Xis CRor nitrogen, Ris independently hydrogens, etc., n is 0, 1, 2, 3 or 4; -D-Y is &#x2014;O&#x2014;CHCOOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels. 

Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers

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Osaka, Japan

Miki Hirai