Sumitomo Dainippon Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Miki Hashizume

Hitoshi Ban

Seiji Kamioka

Futoshi Hasegawa

Yusuke Sawayama

Shingo Tojo

Manabu Kusagi

The present invention relates to the compound of formula (I) wherein R, R, R, and Rare hydrogen atom, etc., Rand Rare hydrogen atom, etc., R, R, R, and Rare hydrogen atom, etc., L is bond, etc., V is Calkylene, Q is optionally-substituted imidazole, or a pharmaceutically acceptable salt thereof, as a novel anti-tumor agent that targets CSCs which are thought to be closely involved in the persistent proliferation of malignant tumor, metastasis or recurrence of cancer, and resistance to anti-tumor agents.

Dihydrochromene derivatives

The present invention provides a 1,4-disubstituted imidazole derivative of formula (1') wherein ring Qis optionally-substituted Caryl group, etc.; Rand Rare independently hydrogen atom, etc.; Wis optionally-substituted Calkylene group; Wis &#x2014;NRC(O)&#x2014; wherein Ris hydrogen atom or Calkyl group, etc.; ring Qis 5- to 10-membered heteroaryl group, etc.; Wis optionally-substituted Calkylene group, etc.; n is 1, 2, 3, 4, or 5; Ris independently halogen atom, optionally-substituted Calkyl group, etc.; Ris hydroxy group, etc.; and a pharmacologically acceptable salt thereof, which have a potent inhibitory effect on the sphere-forming capacity of cancer cells and are useful as an orally-available anti-tumor agent. 

1,4-disubstituted imidazole derivative

The present invention relates to the compound of formula (I) wherein R, R, R, and Rare hydrogen atom, etc., Rand Rare hydrogen atom, etc., R, R, R, and Rare hydrogen atom, etc., L is bond, etc., V is Calkylene, Q is optionally-substituted imidazole, or a pharmaceutically acceptable salt thereof, as a novel anti-tumor agent that targets CSCs which are thought to be closely involved in the persistent proliferation of malignant tumor, metastasis or recurrence of cancer, and resistance to anti-tumor agents. 

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Osaka, Japan

Miki Hashizume