Novocure Gmbh

Mikhail Shtotland

Yoram Wasserman

Michael Krinitsky

Victor Kaikov

Edward Langerman

Sergei Kirillov

TTFields therapy is a proven approach for treating tumors using electric fields. This application describes systems and methods for measuring the temperature at the electrode elements of the transducer arrays that are used to apply the TTFields to a subject. A distal circuit is positioned adjacent to each transducer array, and the distal circuit interfaces with temperature sensors in the transducer array to obtain temperature readings. Those temperature readings are transmitted to a central hub. In some embodiments, temperature measurements from all of the distal circuits occur simultaneously.

Temperature measurement in arrays for delivering TTFields

An apparatus for generating a sinusoid at a pre-set frequency f includes a DC power source with a controllable output voltage, a transformer, a power switch, a sequencer, and an output filter. The power switch is configured to apply the output of the DC power source to the primary of the transformer in either direction or to remain off based on control signals that are applied to its control input. The sequencer applies control signals to the control input in a choreographed sequence to form an oversampled version of a sine wave. The output filter is connected to the secondary of the transformer, and it passes the pre-set frequency f and attenuates frequencies above a cut-off frequency. In some preferred embodiments, the cut-off frequency is 3f and the transfer function of the output filter has a zero at 5f.

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Beer Sheva, Israel

Mikhail Shtotland