Pharmacia & Upjohn Company

Vicuron Pharmaceuticals Inc.

Micurx Pharmaceuticals, Inc.

Pfizer Corporation

Versicor, Inc.

Other

Shanghai Micurx Pharmaceutical Co., Ltd.

Mikhail Fedorovich Gordeev

Dinesh Vinoobhai Patel

Gary W Luehr

Michael R Barbachyn

Adam Renslo

Sampath Kumar Anandan

Jason G Lewis

Xinghai Wang

Jinqian Liu

Eric M Gordon

Zhi-Jie Ni

Zhengyu Yuan

Hardwin O'Dowd

Robert C Gadwood

Jason Gustaf Lewis

Richard Charles Thomas

Toni-Jo Poel

James R Gage

Upinder Singh

Stuart Lam

Neil E Westlund

Liansheng Li

Rakesh K Jain

Vara Prasad Venkata Nagendra Josyula

Charles Francavilla

Sampath-Kumar Anandan

Gary W Leuhr

Xueliang Zhang

Vara Prasad Venkata Negandra Josyula

The present invention relates to a pharmaceutical crystal of contezolid acefosamil, a preparation method therefor, and uses thereof. The present invention also relates to a crystal or crystal complex of formula I, wherein R is selected from hydrogen, sodium or a mixture thereof in any ratio.

Pharmaceutical crystal of contezolid acefosamil, preparation method therefor, and uses thereof

The present invention provides antimicrobial polymyxin compounds of the following formula I: or pharmaceutically acceptable salts, hydrates, or solvates thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Antimicrobial polymyxins for treatment of bacterial infections

The present invention provides certain water-soluble O-carbonyl phosphoramidate prodrugs of the following formula I: or pharmaceutically acceptable salts thereof that are therapeutic or antibacterial agents, pharmaceutical compositions containing them, methods for their use, and reagents and methods for preparing these compounds.

Water-soluble O-carbonyl phosphoramidate prodrugs for therapeutic administration

Provided herein are antimicrobial tricyclic boron compounds of the following formula I: or pharmaceutically acceptable salts, complexes, or tautomers thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Tricyclic boron compounds for antimicrobial therapy

The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections

Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) eachindicates a point of attachment. 

N-hydroxyamide derivatives possessing antibacterial activity

The present invention provides antibacterial agents having the formulae I, II, and III described herein.

N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Ris Calkyl, optionally substituted with a fluoro atom, or Ris a cyclopropyl or cyclopropylmethyl; and Ris methyl or ethyl. These compounds are useful as antibacterial agents.

7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin derivatives possessing antibacterial activity

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin derivatives possessing antimicrobial activity

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is &#x2014;S(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;NR)&#x2014;, or &#x2014;S(&#x2550;NR)(&#x2550;O)&#x2014;; Z is &#x2014;NHC(&#x2550;O)R, &#x2014;NHC(&#x2550;S)R, &#x2014;NH-het, &#x2014;O-het, &#x2014;S-het, or -het. The compounds of formula I are useful as antibacterial agents.

Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

Growing community of inventors

Castro Valley, CA, United States of America

Mikhail Fedorovich Gordeev