University of California

Mike Whitney

Roger Y Tsien

Quyen T Nguyen

Stephen R Adams

Dina Hingorani

The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostic and therapeutic delivery

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic delivery

Disclosed herein, the invention pertains to methods and compositions that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a MTS molecule of the present invention. In some embodiments, a MTS molecule disclosed herein has the formula (A-X-B-C), wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and C is a detectable moiety.

Personalized protease assay to measure protease activity in neoplasms

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San Diego, CA, United States of America

Mike Whitney