Forsight Vision4, Inc.

Mike Barrett

Eugene De Juan, Jr

Signe R Erickson

Randolph E Campbell

Darren G Doud

Christina Skieller

David Batten

K Angela Macfarlane

Kathleen Cogan Farinas

Greg Stine

Cary J Reich

Yair Alster

Douglas Sutton

Eugene De Juan

Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Injector apparatus and method for drug delivery

An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Fluid exchange apparatus and methods

Described herein is an apparatus to insert an implantable therapeutic device into a patient. The apparatus includes a proximal handle () and a distal placement portion () coupled to the proximal handle and configured to hold the implantable therapeutic device. The distal placement portion includes a first side () having a first engagement structure () at a distal end of the first side, the first engagement structure configured to surround at least a first portion of a proximal end region of the implantable therapeutic device. The distal placement portion includes a second, opposite side () having a second engagement structure () at a distal end of the second side, the second engagement structure configured to surround at least a second, opposite portion of the proximal end region of the implantable therapeutic device.

Insertion and removal methods and apparatus for therapeutic devices

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Menlo Park, CA, United States of America

Mike Barrett