Banyu Pharmaceutical Co. Ltd

Msd K.k.

Mikako Kawamura

Takashi Hashihayata

Yoshikazu Iwasawa

Morihiro Mitsuya

Fuyuki Yamamoto

Yoshiyuki Sato

Toshihiro Sakamoto

Tadashi Shimamura

Nobuhiko Kawanishi

Hidetomo Furuyama

Takeshi Sagara

Takashi Mita

Hiroshi Hirai

Satoshi Sunami

Takashi Yoshizumi

Sachie Arai

Tetsuya Sugimoto

Hideki Kurihara

Hideya Komatani

Kaori Kamijo

Hidetomo Fruyama

The invention relates to compounds of general formula (I-0): wherein R, R, R, R, R, R, R, R, X, and Y are as defined herein. Compounds of the invention have, based on excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and are therefore useful in the field of medicine.

Pyridone-substituted-dihydropyrazolopyrimidinone derivative

The present invention relates to a compound represented by Formula [I]: or a pharmaceutically acceptable salt or ester thereof, wherein Rand R, which may be the same or different, are each a hydrogen atom, a lower alkyl group, a cycloalkyl group, or the like; Rand R, which may be the same or different, are each a hydrogen atom, a lower alkyl group, NRR, a phenyl group, a lower alkyl group substituted with a phenyl group, a 4-to 7-membered aliphatic heterocyclic group, a lower alkyl group substituted with a 4- to 7-membered aliphatic heterocyclic group, a 5-or 6-membered aromatic heterocyclic group, a lower alkyl group substituted with a 5-or 6-membered aromatic heterocyclic group, or the like; and Ris a hydrogen atom, a cyano group, a halogen atom, or a lower alkyl group.

Aminopyrimidine derivatives as PLK1 inhibitors

The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein:

Substituted imidazole derivative

The present invention relates to a compound represented by Formula [I]: wherein

Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton

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Tsukuba, Japan

Mikako Kawamura