Sony Corporation

Tohoku University

Ono Pharmaceutical Co., Ltd.

Zenoaq Resource Co., Ltd.

Zenogen Pharma Co., Ltd.

Mika Kaneko

Yukinari Kato

Shuichi Kikuchi

Yuji Iwaki

Tsuneo Nemoto

Toshiro Kobayashi

Satoshi Ogasawara

Masayuki Kurogi

Daisuke Nakayama

An antibody or antigen-binding fragment thereof is disclosed. The antibody or antigen-binding fragment thereof binds to HER2 expressed on a cancer cell or a fragment of the HER2. A HER2-targeting agent containing any of the antibody or antigen-binding fragment thereof, and a pharmaceutical composition containing the HER2-targeting agent are disclosed.

HER2 targeting agent

The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of introducing a nucleic acid encoding all or a portion of podocalyxin into cells expressing a cancer cell-specific sugar chain structure to cause cancer cell-specific podocalyxin or a portion thereof to be expressed therein, a step of immunizing a non-human mammal with the cancer cell-specific podocalyxin or portion thereof to obtain antibodies, and a step of purifying the antibodies by primary screening using purified cancer cell-specific podocalyxin or a portion thereof.

Cancer cell specific anti-podocalyxin antibody and method for producing same

A storage case for disc-shaped recording media contained within respective substantially flat rectangular housings is constituted by a one-piece molded plastic member including a central spine having opposed side edges joined by flexible hinges with respective rectangular covers which are swingable between closed positions, in which the covers extend substantially parallel to each other from the spine with their inner surfaces in confronting relation, and opened positions in which the covers are spread angularly apart, elements on the covers for holding respective disc-shaped recording media in their rectangular housings against the inner surfaces of the respective covers, and a holder on the spine extending from the latter between the covers in the closed positions of the latter for embracing and holding at least one additional disc-shaped recording medium at an edge portion of its respective rectangular housing so as to accommodate such at least one additional disc-shaped recording medium in its respective housing between the disc-shaped recording media in their respective housings held against the inner surfaces of the covers.

Storage case for disc-shaped recording media contained within

In a disk cartridge in which a sheet-like recording medium is fixed to the periphery of a circular center plate which has an approximately square center hole and an almost rectangular eccentric driving hole, and a cartridge rotatably accommodating the sheet-like recording medium and including an upper half and a lower half having a turntable insertion hole in which the circular center plate is loosely fitted; the sheet-like recording medium is positioned in the cartridge by restricting the movement of the circular center plate at the central portion thereof, so that the diameter of the circular center plate can be substantially decreased and aberration of tracking or the like during recording or reproducing is avoided as much as possible.

Magnetic disk cartridge with improved center plate for disk mounting

Growing community of inventors

Miyagi, Japan

Mika Kaneko