Delsitech Oy

Other

Vivoxid Oy

Mika Jokinen

Harry Gosta Jalonen

Timo Peltola

Harry Jalonen

Antti Yli-Urpo

Sinikka Veittola

Ari-Pekka Forsback

Pirjo Kortesuo

Manja Ahola

Lasse Leino

Mika Koskinen

Timo Närhi

Reeta Viitala

Hannu Paldan

Risto-Pekka Happonen

Panu Noppari

Minna Vaahtio

Mika Kaimainen

This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analog reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analog reverse transcriptase inhibitor and having a maximum diameter of &#x2264;1 000 &#x3bc;m, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.

Hydrogel composite depot formulation

A method for preparing a sol-gel derived SiOhaving a very fast bioresorption rate where a sol-gel derived SiOis prepared from a sol comprising water, an alkoxide or inorganic silicate and a lower alcohol using a mineral acid or a base as a catalyst and the sol is aged and dried. The method uses a pH from 1.5 to 2.5, a molar ratio of water to the alkoxide or inorganic silicate of 0.5 to 2.5, a molar ratio of alcohol to the alkoxide or inorganic silicate is &#x2265;0.5; and the sol is either let to gel without induced changes of composition and without forced drying of the sol, or a change of composition is induced; and within a time of &#x2264;30 minutes, from the induced change forced drying of the sol is carried out or initiated.

[object Object]

This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.

Silica hydrogel composite

A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.

Method for storing silica-based material, package produced with the method and use of package for packaging of silica-based products

A method for preparing controllably biodegradable silica fibres which includes spinning the fibres from a silica sol of controlled viscosity, controllably biodegradable silica fibres prepared according to the method, methods for controlling the biodegradability of the fibres, the use of controllably biodegradable fibres as sustained and/or controlled release delivery devices for biologically active agents, and pharmaceutical preparations containing such devices.

Biodegradable ceramic fibres from silica sols

A method for improving soft tissue attachment which includes the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiOand/or SiO, and applying the coating where soft tissue attachment is desired. An implant in which a surface or surfaces of the implant intended to be attached to soft tissue are coated with a porous coating rich in TiOand/or SiO, and the use of a porous surface coating rich in TiO, SiO, or TiOand SiO, for the manufacture of an implant for soft tissue attachment are also disclosed.

Method for improvement of soft tissue attachment and implants making use of said method

This invention relates to bioactive sol-gel derived silica fibers, methods for their preparation, an implantable device comprising the fibers and the use of the device for tissue guiding or bone repair.

Bioactive sol-gel derived silica fibers and methods for their preparation

Growing community of inventors

Turku, Finland

Mika Jokinen