Takeda Pharmaceutical Company Limited

Mika Goto

Masaaki Mori

Yukio Shimomura

Takuya Watanabe

Chieko Kitada

Shigenori Ohkawa

Taiji Asami

Tetsuya Tsukamoto

Tsukasa Sugo

Yoshio Matsumoto

Yoshihiro Kiyota

Mioko Harada

Yuka Adachi

Michiko Abe

Shouzou Yamamoto

Masato Shimojou

Masaki Setou

The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as the DNA encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing receptor-binding assay systems with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.

Ligand to GPR8

A cannabinoid receptor modulator containing a compound represented by Formula (I) wherein, X is an oxygen atom, etc., Ris an optionally substituted acylamino group, ring Ais a benzene ring which may further have a substituent in addition to R, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.

Cannabinoid receptor modulator

The present invention provides preventive/therapeutic agents for anorexia nervosa and preventive/therapeutic agents for obesity. More specifically, the present invention provides a method and kit for screening a compound or its salt that changes the binding properties of GPR7 to a polypeptide capable of binding specifically to GPR7.

Method of screening preventives or remedies for obesity

The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as DNA, encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.

Peptide having appetite stimulating activity

Growing community of inventors

Nishinomiya, Japan

Mika Goto