Ajinomoto Co., Ltd.

Miho Ono

Masahiro Murata

Toshihiko Yoshimura

Tatsuya Okuzumi

Yuji Tanaka

Kazuyuki Sagi

Eiji Nakanishi

Hideki Matsumoto

Manabu Suzuki

Akira Chiba

Hiroyuki Izawa

Tomoko Takeda

Tetsuo Yano

Masaki Hashimoto

Tomohisa Okutsu

Hideki Suzuki

Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-&#x3b1;. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-&#x3b1; production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

Therapeutic agent for inflammatory bowel disease and TNF-&#x3b1; production inhibitor

Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning &#x3b1;4 integrin in which &#x3b1;4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj&#xf6;gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.

Phenylalanine derivatives

The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to &#x3b1;4 integrin and therapeutic agents for various diseases concerning &#x3b1;4 integrin. 

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Kawasaki, Japan

Miho Ono