Hiroshima Industrial Promotion Organization

Riken Corporation

Hiroshima University

Phoenixbio Co., Ltd.

Biointegrence Inc.

Miho Kataoka

Katsutoshi Yoshizato

Chise Mukaidani

Tatsuhiko Tsunoda

Fuyuki Miya

Norio Masumoto

Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.

Nonalcoholic steatohepatitis model rodent and fatty liver model rodent

Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.

Method of treating mouse carrying human hepatocytes

Growing community of inventors

Kumamoto, Japan

Miho Kataoka