Kyowa Hakko Kogyo Co., Ltd.

Miho Iwase

Etsuo Ohshima

Ichiro Miki

Hitoshi Arai

Kimihisa Ueno

Satoshi Nakanishi

Seiji Aratake

Koji Suzuki

Koji Yanagawa

Hiroshi Ishida

Tsutomu Matsumura

Motoki Miyama

Katsuya Kobayashi

Yosuke Yamaura

Ari Kawabe

Takashi Sato

Shinya Fujii

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); Rrepresents the above Formula (II), Formula (IV) or the like; A represents a single bond, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;OC(&#x2550;O)&#x2014; or the like; and Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

Bicyclic pyrimidine derivatives

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Sunto-gun, Japan

Miho Iwase