Pharmacyclics, Inc.

Miguel Rosingana

Gregory W Hemmi

William C Dow

Joan F Carvalho

A method has been developed which utilizes a metal-2,4-dicarbonyl complex as an organic solvent soluble metal ion source in the metallation of polyazamacrocycles including porphyrins, expanded porphyrins and porphyrinoid compounds. Use of a metal ion source which is soluble in the metallation reaction medium produces significantly higher yields of a measurably purer product than is achieved using an insoluble or only sparingly soluble metal salt as in the prior art. Additionally, because the metallation can be performed in relatively concentrated mixtures, the reaction times are dramatically shorter and the amount of waste produced is less than when simple metal salts serve as the metal ion source. Further, use of the soluble metal-2,4-dicarbonyl complex simplifies the purification protocol required for the metallated expanded porphyrin.

Metallation of macrocycles with 2,4-dicarbonyl-metal complexes

A process for the isolation of sp.sup.3 reduced nonaromatic macrocyclic texaphyrin precursors, aromatic texaphyrin compounds and texaphyrin-metal complexes from aqueous salt solutions.

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San Francisco, CA, United States of America

Miguel Rosingana