Laboratorios Made, S.a.

Knoll Aktiengesellschaft

Basf Aktiengesellschaft

Laboratories Made, S.a.

Laboratories Knoll, S.a.

Miguel Fernandez Brana

Jose Maria Berlanga

Cristobal M Roldan

Jose Maria Castellano Berlanga

Cynthia A Romerdahl

Gerhard Keilhauer

Marina Moran Moset

Xiao-Dong Qian

Cristobal Martinez Roldan

Peter Bousquet

Rafael P Alvarez-Ossorio

Antonio M Sanz

Reinhard Spengler

Erich Schlick

Maria Luz Lopez Rodriguez

Christine Tetzner

Maria Jesus De Vega

Maria Jesus Perez De Vega

Christobal Martinez Roldan

Cristina R Fernandez De Gamboa

Cristina R De Gamboa

Jose L Soto Camara

Jesus G Garcia

Disclosed herein are compounds pharmaceutical compositions containing same of the formula

Bis-naphthalimides for the treatment of cancer

Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X' and X'', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

Novel bis-1,2-dihydro-3H-dibenzisoquinoline-1,3-diones and their salts, processes for their preparation, pharmaceutical compositions containing them and methods of using them to treat malignancies, mainly human solid tumor carcinomas.

Dihydrodibenzisoquinolinediones

The monohydrochloride and the monomethanesulfonate of amonafide are described. The salts have good pharmaceutical properties besides their antitumor action.

Amonafide salts

N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide (amonafide) is an effective agent for the treatment of leukemias and solid tumors.

Method for treating leukemias using

Bisnaphthalimides of the formula I ##STR1## where X.sup.1 to X.sup.4 and R have the meanings stated in the description, and their preparation are described. The compounds are cytotoxic towards human cells in vitro.

Bisnaphthalimides

1,2-diacylamino-1,2-di(4-pyridil)ethanes of general formula: ##STR1## where R is a saturated or unsaturated alkyl group, a homocyclic or heterocyclic aromatic ring, with or without substituents, or a saturated or unsaturated cycloalkyl. Said compounds are useful as analgesic. A process for preparing such products is also described.

1,2-Diacylamino-1,2-di(4-pyridyl)ethanes and process for producing

N-substituted-3-substituted naphthalimides are prepared by reacting 3-substituted naphthalic acid with a compound having a primary amino group. The naphthalimides possess cytotoxic properties.

N(Aminoalkyl)-naphthalimides and their derivatives

Compounds having the formula ##STR1## wherein Y is 2-dimethylaminoethyl, 2-diethylaminoethyl, 2-(N-pyrrolidino)ethyl or 2-(N-piperidino)ethyl. The compounds are prepared by reacting 3-nitronaphthalic acid, or corresponding anhydride, with the corresponding primary amine. The compounds possess cytostatic and raticide properties.

N-Aminoethyl-substituted-3-nitronaphthalimides

The invention relates to the compound 5-Hydroxytryptophan Glutamate, having anti-depressive action.

Compounds 5-hydroxytryptophan glutamate and its derivatives

The 7-theophylline acetic acid salt of mepyramine possesses bronchial spasmolytic, antiarrhythmic, cerebral oxidation inhibitor and platelet aggregation inhibitor properties. It is prepared by slowly adding a solution of mepyramine to a suspension of 7-theophylline acetic acid in the same solvent to effect the salt-forming reaction. It can be incorporated in various pharmaceutical unit dosage forms.

Mepyramine theophylline acetate

Compounds having the formula ##EQU1## wherein R is 2-picolyl, 3-picolyl or 4-picolyl. The compounds are prepared by reacting dipropylacetic acid, or the corresponding chloride or anhydride, with 2-picolylamine, 3-picolylamine or 4-picolylamine. The compounds possess anti-convulsant and barbiturate potentiation properties.

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Madrid, Spain

Miguel Fernandez Brana