Other

Basf Aktiengesellschaft

Knoll Aktiengesellschaft

Miguel F Bra Na

Cynthia A Romerdahl

Gerhard Keilhauer

Xiao-Dong Qian

Marina Moran Moset

Peter Bousquet

Marina Mor An Moset

Mar Ia P Erez De Vega

Jos E Castellano Berlanga

Jos E Berlanga

Jose Mc Berlanga

Maria Jp De Vega

Erich Schlick

Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X' and X'', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

Bis-naphthalimides for the treatment of cancer

Asymmetrically substituted bisnaphthalimides

An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I ##STR1## where n is 1 or 2, R.sup.1 and R.sup.2 are identical or different and are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R.sup.3 and R.sup.4 are identical or different and are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -acyl, C.sub.2 --C.sub.7 -alkoxycarbonyl, ureyl, aminocarbonyl or C.sub.2 -C.sub.7 -alkylaminocarbonyl, and its salts with physiologically tolerated acids, are described.

5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and their use

Growing community of inventors

Madrid, Spain

Miguel F Bra Na